Chalcone 3: Development of First-in-Class Invasion Inhibitors for the Treatment of Metastatic Cancers (Chalcone 3)

To date, there are no effective anti-invasive / antimetastatic drugs available in the clinic. There is a great need for anti-invasive therapies. These would not only be useful in patients with localized tumors, but also in patients who already show metastases at diagnosis. The agents can then still inhibit the development of secondary metastases, as well as therapy-induced metastases. We have developed three sets of synthetic molecules that very effectively inhibit invasion at nM concentrations in a series of in vitro models for a range of human tumor cell lines. The aim of the project is to further develop our assets in an incubation track in order to achieve a spin-off.