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Publication

Normalization of 14-3-3 in CJD

Journal Contribution - Journal Article

We report on a 47-year-old woman with autopsy proven Creutzfeldt-Jakob disease (CJD), who had a positive initial 14-3-3 test but a subsequent negative test under pharmacologic suppression of the periodic epileptiform discharges on EEG. Multiple factors associated with a subsequent 14-3-3 test becoming negative are known. However none of these circumstances were applicable to our patient. This case history suggests sedative therapy in CJD may induce false negative 14-3-3 testing. This appears to be a relevant finding, since the differential diagnosis between non-convulsive status epilepticus and CJD is not always evident in the initial stage of the disease and some patients with CJD present with seizures.
Journal: Acta Neurologica Belgica
ISSN: 0300-9009
Issue: 2
Volume: 108
Pages: 64 - 66
Publication year:2008
BOF-keylabel:yes
IOF-keylabel:yes
BOF-publication weight:0.5
CSS-citation score:1
Authors from:Higher Education
Accessibility:Closed