Magnetofluorescent Nanoaggregates Incorporating Terbium(III) Complexes as Potential Bimodal Agents for Magnetic Resonance and Optical Imaging

Terbium(III) was coordinated to two diethylene triamine pentaacetic acid (DTPA) amphiphilic bisamide ligands and the complexes were assembled into micellar nano-aggregates. The magnetic and optical properties of the resulting nano-aggregates were examined in detail. Upon excitation into the ligand levels at 265 nm, the complexes show characteristic Tb(III) emission at 546 nm with quantum yields reaching 7.6%. Nuclear Magnetic Relaxation Dispersion (NMRD) measurements have shown that transverse relaxivity r2 at 500 MHz and 310 K reaches maximum values of up to 9.4 s-1 mM-1. The efficient T2 relaxivity at high magnetic field strengths is sustained by the increased rotational correlation time of the nano-aggregates and high magnetic moment of the terbium ion.

Publication year:2015

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Authors from:Higher Education

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