Magnetofluorescent micellar complexes of terbium(III) as potential bimodal contrast agents for magnetic resonance and optical imaging

Terbium(III) was coordinated to four novel 1,4,7,10-tetra- azacyclododecane-1,4,7,10-tetraacetic acid (DOTA) amphiphilic bisamide ligands. The complexes were assembled into mono- disperse micellar nano-aggregates and for the first time TbIII has been evaluated as a single lanthanide negative bimodal contrast agent for MRI/OI. The complexes show characteristic TbIII emission with quan- tum yields reaching 7.3% and transverse relaxivity r2 per TbIII micelle at 500MHz and310 Kreaches maximumvalues upto60s?1 micelle?1. The efficient T2 relaxation at highmagnetic field strengths is sustained by the increased rotational correlation time of the nano-aggregates and high magnetic moment of the terbium ion.

Publication year:2015

BOF-keylabel:yes

IOF-keylabel:yes

BOF-publication weight:2

CSS-citation score:1

Authors from:Higher Education

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