Extracellular matrix proteins as temporary coating for thin-film neural implants

OBJECTIVE: This study investigates the suitability of a thin sheet of extracellular matrix (ECM) proteins as a resorbable coating for temporarily reinforcing fragile or ultra-low stiffness thin-film neural implants to be placed on the brain, i.e. microelectrocorticographic (µECOG) implants. APPROACH: Thin-film polyimide-based electrode arrays were fabricated using lithographic methods. ECM was harvested from porcine tissue by a decellularization method and coated around the arrays. Mechanical tests and an in vivo experiment on rats were conducted, followed by a histological tissue study combined with a statistical equivalence test (confidence interval approach, 0.05 significance level) to compare the test group with an uncoated control group. MAIN RESULTS: After 3 months, no significant damage was found based on GFAP and NeuN staining of the relevant brain areas. SIGNIFICANCE: The study shows that ECM sheets are a suitable temporary coating for thin µECOG neural implants.

Publication year:2017

BOF-keylabel:yes

IOF-keylabel:yes

BOF-publication weight:1

CSS-citation score:1

Authors:International

Authors from:Government, Higher Education

Accessibility:Open