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Publication

Transgenic Artifacts Caused by Passenger Human Growth Hormone

Journal Contribution - Journal Editorial

The minigene encoding human growth hormone (hGH) has been incorporated into over 300 transgenic mouse lines to improve transgene expression. However, unexpected and functional hGH expression can drastically alter physiology. We list here the mouse lines in which ectopic hGH has been confirmed, and we provide a wiki for lines awaiting analysis.
Journal: Trends in Endocrinology and Metabolism
ISSN: 1043-2760
Issue: 10
Volume: 29
Pages: 670 - 674
Publication year:2018
Accessibility:Closed