Genetic origin of congenital heart defects in Tunisian population ( a clinical and laboratory approach)

Congenital heart defects (CHD) are the most common type of birth defect and account for nearly one-third of all major congenital anomalies. In Tunisia, CHD represent a major cause of infant morbidity and mortality. Their incidence is estimated to be 6.8 per 1000. The general objective of this study is to determine the genetic causes of congenital heart defects in Tunisian patients. This knowledge and expertise thus gained will contribute to a better etiological diagnosis of CHD and earlier and better medical care, in order to improve survival of these children born. Moreover, this will improve genetic counseling for the families.