Choriocarcinoma in situ in a partial hydatidiform mole: A case report

© Journal of Reproductive Medicine®, Inc. BACKGROUND: Choriocarcinoma most frequently arises in a complete hydatidiform mole. Less common are cases following a normal pregnancy or a nonmolar abortion. Its occurrence after a partial hydatidiform mole is extremely rare. CASE REPORT: Here we report a choriocarcinoma in situ diagnosed after dilation and curettage for a first trimester partial hydatidiform mole. The diagnosis was con firmed by immunohistochemistry, fluorescent in situ hybridization, and microsatellite instability genotyping of the products of conception and blood of the mother and father. We demonstrated a diandric triploidy. At the time of diagnosis CT scan showed lung metastasis. The patient was classified as high-risk gestational trophoblastic neoplasia and treated with high-dose methotrexate-etoposide. CONCLUSION: This is the first reported case of a choriocarcinoma arising in a first trimester partial mole.

Publication year:2016