Targeted photoablation and targeted synchronised photostimulation of atrial cardiomyocyties in hIPSC-CM culture.

In classical ablation, radiofrequency energy is used to destroy cardiac tissue in order to treat arrhythmias. The effects of ablation are rather aspecific. In this project, we want to explore a much more selective targeting of myocytes, that are first labeled by gold containing specific antibodies. With antibodies that are directed specifically to atrial myocytes, we want to prove in cultures of human induced pluripotent stem cells that only the atrial myocytes (but not ventricular of nodal ones) can selectively be destroyed by applying photoenergy.

Keywords:RADIOFREQUENCY

Disciplines:Biophysics, Laboratory medicine, Palliative care and end-of-life care, Regenerative medicine, Other basic sciences, Other clinical sciences, Other health sciences, Nursing, Other paramedical sciences, Other translational sciences, Other medical and health sciences