Safety and efficacy of intrathecal rituximab in children with B cell lymphoid CD20+ malignancies: An international retrospective study

Central nervous system (CNS) involvement in patients with mature B non-Hodgkin lymphoma, post transplantation proliferative disorder and acute lymphoblastic leukaemia confers a significantly inferior prognosis as compared to patients without CNS disease. Intrathecal (IT) or intraventricular administration of rituximab is an option for this group of patients. We report 25 children with CNS involvement of CD20+ B lymphoid malignancies who received in total 163 IT/intraventricular rituximab doses. The median number of doses received by each patient was 6, with a median dose of 25 mg. The most common adverse events were grade 1 and 2 peripheral neuropathies in five patients (20%), allergy in two patients, and headache in two patients. These events were self-limited, occurring in the 48 hours after treatment and resolving within 24 hours. Three patients presented with more severe though transient side effects, one with a grade III neuropathy and two with seizure. Eighteen patients (72%) of those treated with IT/intraventricular rituximab, with or without other CNS directed treatment, achieved a CNS remission. This case series suggests that IT/intraventricular rituximab has therapeutic efficacy and relatively limited toxicity. Prospective trials of IT/intraventricular rituximab for patients with CNS involvement of CD20+B lymphoid malignancies are warranted. This article is protected by copyright. All rights reserved.

Publication year:2016

BOF-keylabel:yes

IOF-keylabel:yes

BOF-publication weight:3

CSS-citation score:1

Authors:International

Authors from:Higher Education

Accessibility:Closed