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Project

The epigenetic effects of air pollutants on human Amniotic Fluid Stem Cells (hAFSCs)

Literature indicates that environmental pollution affects human reproductive health. Air pollution is a major environmental issue that has been related to negatively impact quality of gametes, embryonic development and health in subsequent generation(s). However, mechanisms how these air born pollutants can reach and affect a growing embryo are not completely understood in humans. In the current study we aim to measure specific pollutants in human embryonic matrices. Besides quantifying their presence, we will also measure biological effects from exposure to air pollution. This will be donne through an in vitro model where we will measure how the epigenome of embryonic tissues is affected after exposure to mixtures of pollutants. Our study will help understand how air born pollutants -present in our environment affect human development and long-term offspring health.

Date:1 Nov 2017 →  28 Jul 2020
Keywords:epigenetics, human Amniotic Fluid Stem Cells, Air pollution
Disciplines:Public health care, Public health sciences, Public health services, Animal biology, Genetics, Systems biology, Molecular and cell biology, Other biological sciences
Project type:PhD project