Distributed task coding throughout the multiple demand network of the human frontal-insular cortex

The large variety of tasks that humans can perform is governed by a small number of key frontal-insular regions that are commonly active during task performance. Little is known about how this network distinguishes different tasks We report on fMRI data in twelve participants while they performed four cognitive tasks Of 20 commonly active frontal-Insular regions in each hemisphere, five showed a BOLD response increase with increased task demands, regardless of the task Although active in all tasks, each task invoked a unique response pattern across the voxels in each area that proved reliable in split-half multi-voxel correlation analysis Consequently, voxels differed in their preference for one or more of the tasks Voxel-based functional connectivity analyses revealed that same preference voxels distributed across all areas of the network constituted functional sub-networks that characterized the task being executed (C) 2010 Elsevier Inc All rights reserved

Publication year:2010

BOF-keylabel:yes

IOF-keylabel:yes

BOF-publication weight:10

CSS-citation score:2

Authors:International

Authors from:Higher Education