The (patho)genetic study of bicuspid aortic valve and associated aortic aneurysm.

The general aim of this project is to unravel the underlying genetic basis and to gain insight into the pathogenic mechanisms leading to BAV-associated aneurysm formation in order to advance the knowledge significantly beyond the current understanding. We will take advantage of the era of next generation sequencing, which is now offering unprecedented opportunities for a major breakthrough in the field of BAV/TAA.

Keywords:AORTIC ANEURYSM, CELL BIOLOGY, PATHOGENESIS

Disciplines:Genetics, Systems biology, Molecular and cell biology