Phase II Study of isolated lung perfusion combined with pulmonary metastasectomy for the treatment of patients with operable lung metastases from colorectal carcinoma, osteosarcoma or soft tissue sarcoma

Due to its filtering capacity for the entire circulation, the lung is a common site for malignant disease. Among patients with metastic cancer, 20-30 % will have secondary spread to the lung according to necropsy series. The poor results of surgical resection of pulmanory metastases from osteogenic sarcomas, soft tissue sarcomas and colorectal adenocarcinomas are probably due to genetic drug resistance and the inability to achieve effective drug concentrations within the tumor mass. In this way, isolated lung perfusion can be a promising procedure for the treatment of tumors metastatic to the lungs which are surgically unresectable and unresponsive to conventional chemotherapy. It has the advantage of both selectively delivering an agent and diverting the venous effluent. This allows the drug to to be delivered in a higher dose without systemic complications.

Keywords:LUNG METASTASEN, ISOLATED PULMONARY PERFUSION, TUMOR NECROSIS FACTOR

Disciplines:Morphological sciences, Oncology, Orthopaedics, Surgery, Nursing