Effects of TLR-ligand loaded leukemic cells and type I IFN on dendritic cell-induced tumor-specific T-cell immunity.

The subject of this PhD project has to be situated within the framework of existing research activities at the Laboratory of Experimental Haematology focusing on the effects of innate immune signals on leukaemic tumor cells. This project aims to augment the immunogenicity of leukaemic cells through Toll-like receptor stimulation in order to (1) modulate the maturation stage of dendritic cells and to (2) subsequently potentiate a powerful acute myeloid leukemia-specific T-cell response.

Keywords:LEUKEMIA, DENDRITIC CELLS

Disciplines:Systems biology, Hematology, Immunology, Laboratory medicine, Morphological sciences, Oncology