Characterization and modulation of microglial responses following transplantation of allogeneic bone marrow-derived stromal cells in the central nervous system of immune competent mice.

The short/long term survival of allogeneic bone marrow-derived stromal cell grafts will be determined through a combination of non-invasive in vivo imaging techniques, immunohistochemical analyses specific for different involved cell types and immunological assays (ELISPOT). The stromal cells will be genetically manipulated to express neuro-immune regulatory proteins in order to modulate microglial responses.

Keywords:MICROGLIA, TRANSPLANTATION, IMMUNOLOGY, STEM CELLS

Disciplines:Immunology, Morphological sciences