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Project
Influence of dosage, administration route and intestinal health on antibacterial resistance selection in pig intestinal commensal flora and optimization of dosage regimen of selected antibacterial drugs.
The posology of currently available antimicrobials was determined solely based on clinical efficacy and outcome, without taking resistance selection into account. The goal of present study is to evaluate the effect of dosage (over- and underexposure), route of administration (oral and parental) and intestinal health (inflammation) on resistance selection in the commensal microbiota of pigs.
Date:1 Jan 2015 → 30 Jun 2018
Keywords:dosage, pigs, antimicrobials, resistance, administration route
Disciplines:Biomarker discovery and evaluation, Veterinary medicine, Medicinal products, Pharmaceutics, Pharmacotherapy, Pharmacology, Other agricultural, veterinary and food sciences, Pharmacognosy and phytochemistry, Animal biology, Other veterinary sciences, Other pharmaceutical sciences, Drug discovery and development, Toxicology and toxinology, Veterinary medicine not elsewhere classified