Targeted depletion or reprogramming of tumour-associated macrophages with engineered nanomedicines

This project aims at the development of nanoparticles that are selectively recognized and taken up by tumor associated macrophages (TAMs). This phenotype of macrophages is known for its pro-tumoral activity. Therefore we will engineer nanoparticles to reprogram TAMs into an anti-tumoral phenotype to allow fora n improved anti-cancer treatment.