Radiation-induced leukemia: response of CD34+ hematopoietic cells to clinical therapy beams

Leukemia is the most important malignancy after radiation exposure during childhood. The high risk of developing leukemia is related to the high sensitivity of the bone marrow, which harbors hematopoietic stem and progenitor cells (HSPCs). This project aims to elucidate the response of HSPCs (CD34+) to clinical therapy beams of different radiation qualities.