Development of a coated-wire potentiometric sensor for detection of DNA variants and mutations

In human genetic diagnostics, there is a large need for instruments that can detect DNA variants and mutations efficiently and cost-effectively. Current fluorescent methods are expensive and often not suitable for extended multiplex analysis. The aim of this study is the development of a potentiometric coated wire sensor that is able to reliably and quickly detect DNA variants, by adapting a successful sensor platform that has been developed previously at the University of Antwerp.

Keywords:DNA ANALYSIS, BIOSENSORS

Disciplines:Inorganic chemistry, Organic chemistry, Theoretical and computational chemistry, Other chemical sciences, Genetics, Systems biology, Molecular and cell biology