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Project

Role of protein crystals in asthma?

Since 1853 it is known that Charcot Leyden crystals are found in asthmatic airways, and here we propose they promote allergy. We combine immunology with structural biology to investigate the structure, function and evolutionary origins of these and related protein crystals. Through novel tool creation and multidisciplinary research, we envisage the unmasking of a novel drugable pathway in asthma.

Date:1 Jan 2017 →  31 Oct 2022
Keywords:epithelial cells, eosinophils, asthma
Disciplines:Plant biology, Medical biochemistry and metabolism, Biophysics, Molecular and cell biology, Systems biology, Respiratory medicine, Immunology, Biochemistry and metabolism, Condensed matter physics and nanophysics, Medicinal and biomolecular chemistry