Analysis of Volatile Organic Compounds from mesothelioma cells with ion mobility spectrometry (IMS).

Malignant pleural mesothelioma (MPM) is an asbestos-related disease with dismal prognosis. In order to improve early detection and management, breath analysis as a new, non-invasive tool for the diagnosis is being explored in previous MesoBreath studies. However, to increase the specificity of the diagnostic breath model, the aim of this study is (I) to compare and identify the volatile organic compounds (VOCs) emitted from different MPM cell lines with Ion Mobility Spectrometry (IMS), (ii) correlate VOCs from MPM cells with VOCs in the breath of MPM patients and (iii) correlate VOCs with MPM pathogenesis in order to find biological links between the model and the disease pathogenesis.

Keywords:VOLATILE ORGANIC COMPOUNDS, BIOMARKER, MESOTHELIOMA

Disciplines:Diagnostics, Laboratory medicine, Morphological sciences, Oncology, Medicinal products