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Project

Role of dipeptidyl peptidase 4 (DPP4) in collagen metabolism and dipeptide homeostasis.

This project aims to unravel the effects of DPP4 inhibition on collagen and collagen-derived dipeptide metabolism. We willdevelop and validate methods to quantify, in biological matrices, dipeptides resulting from DPP4 mediated cleavage. Next, the effects of DPP4 inhibition on the collagen metabolism and the dipeptide profile will be studied in vitro in fibroblast and osteoblast cultures. The in vivo relevance of our findings will be evaluated by studying the effects of long-term DPP4 inhibition in vivo in a rat model of type 2 diabetes. The focus will be on cardiac and renal collagen metabolism and dipeptide levels in plasma, urine and tissues.
Date:1 Jan 2012 →  31 Dec 2015
Keywords:MEDICAL PHYSIOLOGY, DIABETES, RHEUMATOLOGY, MUSCULO-SKELETAL SYSTEMS
Disciplines:Endocrinology and metabolic diseases, Physiology