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Project
Numerical study of the mass transfer and axial dispersion in porous media: an application to liquid chromatography for the correction of the current form of the van Deemter equation (FWOTM648)
The efficiency of liquid chromatography separations depends very strongly on the axial dispersion or band broadening experienced by the analytes when migrating through the separation column. The governing model for the band broadening in LC is the general plate height model (GPHM). This model was originally developed in the 1950's and 60's and has since then not been changed, essentially because it has never been challenged by new experimental results, although it needs to be remarked that most of the modeling work in literature was done using only dummy constants instead of the calculated geometrical constants appearing in the true GPHM.
New findings, resulting from the recent introduction of chromatographic particles with a solid core now reveal that the superior performance of these particles cannot be predicted by the GPHM. This adds up to two other findings I made during my PhD research, which is that the Sh-number and the effective diffusion coefficient appearing in the GPHM have up to now been calculated using erroneous expressions.
In the present project, I therefore want to revisit the other terms and parameters using the same approach as that followed during my PhD study, i.e. using computational fluid dynamics simulation software to study the dispersion and mass transfer of the different sub-processes contributing to the general band broadening, first individually and then gradually combining the different building blocks
New findings, resulting from the recent introduction of chromatographic particles with a solid core now reveal that the superior performance of these particles cannot be predicted by the GPHM. This adds up to two other findings I made during my PhD research, which is that the Sh-number and the effective diffusion coefficient appearing in the GPHM have up to now been calculated using erroneous expressions.
In the present project, I therefore want to revisit the other terms and parameters using the same approach as that followed during my PhD study, i.e. using computational fluid dynamics simulation software to study the dispersion and mass transfer of the different sub-processes contributing to the general band broadening, first individually and then gradually combining the different building blocks
Date:1 Oct 2012 → 15 Aug 2019
Keywords:Mass Spectrometry, Hydroconversion, Structured Catalysts, Environmental Research, Zeolites, Treatment Of Waste, Pollutants, Gas Separation, Bioreactors, Gasification, High Throughput Screening, Liquid Chromatography, Waste Water, Gas Cleaning, Packaging, Recycling Of Waste, Modelling, Fine Chemicals, Separation, Fluidisation, Chemical Waste, Miniaturization, Rapid Screening, Biomass, Combustion, Energy, Zeolite, Adsorption, Chemical Engineering, Catalysis