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Project

'BacVirISG15' - in the framework of ERA-NET Infect-ERA JTC 2016. The Interferon Stimulated Gene 15 (ISG15) modification system in host pathogen interactions: mechanisms, technology and translational potential.

Novel therapeutic strategies against microbial infections remain limited. In this interdisciplinary project we will investigate the host ISG15 system, induced to counteract a wide range of viral and bacterial pathogens. It’s function relies on linkage of the ISG15 molecule to cellular and microbial proteins. Species-specific aspects of the system will be analyzed to examine the therapeutic potential in humans.

Date:1 Apr 2017 →  31 Mar 2020
Keywords:host-pathogen interactions, proteomics, ubiquitin-like
Disciplines:Medical biochemistry and metabolism, Immunology, Laboratory medicine, Systems biology, Microbiology, Biochemistry and metabolism