Mechanosensitive piezo1 as key player in the decidualization and implantation process?

Embryo implantation, an essential step in human reproduction, is a complex process that involves an intimate interaction between an implantation-competent blastocyst and a receptive uterus. The first and physiological contact between those two players will determine successful implantation. A prerequisite in this process is an adapted uterine endometrium that provides a favourable environment for the embryo, and is characterized by a functional luminal epithelium that is able to transmit signals towards the underlying stroma for appropriate decidualization. Not surprisingly, poor endometrial receptivity during IVF has been highlighted as a contributing factor to implantation failure. Multiple studies into the molecular mechanisms behind this process have been conducted, but to date a complete understanding remains elusive. Possible candidates to govern these downstream events are ion channels that serve as cellular sensors. In this research project we aim to characterize the role of mechanosensitive ion channel piezo1 in sensing mechanical and/or chemical stimuli in the endometrial cells and its consecutive role in decidualization and embryo implantation. Thorough understanding of the function and modulation of piezo1 could increase our knowledge of the molecular processes required for successful implantation and might lead to the development of novel therapeutic treatments and higher rates for successful embryo implantations.