Aneurysms - Diagnosis And Personalized Treatment through biomechanical analysis

Aortic aneurysms are a life-threatening condition and there is ample need for improvement of not only the method of diagnosis but also the treatment. Firstly, diagnosis of the aneurysm and especially its risk of rupture or dissection is very challenging. Currently, the decision to operate is based on whether the diameter measured on a CT-image exceeds a single threshold, which leads to numerous false positives and false negatives. Secondly, standard treatment, i.e. a replacement of the aneurysmatic section by an prosthetic graft, is highly invasive and hazardous. With our unique and interdisciplinary consortium, we aim for a solution of both issues, through an integrated biomechanical analysis. On the one hand, a method to reliably estimate rupture risk based on non-invasive pressure measurement and imaging (4D CT and 4D MRI) will be developed. On the other hand, a thorough analysis and suggestions for improvement of a new and promisi ng treatment technique with exostents will be made.

Keywords:aneurysm, mechanical characterization, finite element modeling, exostent, Biomechanics

Disciplines:Biomechanics