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Project
Looks don’t matter, it’s what you do that counts*: Deployment of innovative bio-assays for screening and elucidation of the mechanism of action of new psychoactive substances
New psychoactive drugs (NPS) continously appear on the worldwide drug market. Several NPS classes -amongst which synthetic cannabinoids and synthetic opioids- act via G protein-coupled receptors (GPCRs). This project aims at developing high-throughput screening bio-assays focusing on activity of the NPS, rather than their chemical structure. Improved knowledge on the GPCR signaling mechanisms will be implemented to ameliorate these bioassays.
Date:1 Oct 2017 → 30 Sep 2023
Keywords:G protein-coupled receptors, synthetic opioids, bio-assay, new psychoactive substances, synthetic cannabinoids
Disciplines:Drug discovery and development, Pharmaceutics, Other pharmaceutical sciences, Medicinal products, Pharmacology, Pharmacotherapy, Pharmacognosy and phytochemistry, Toxicology and toxinology, Biomarker discovery and evaluation