The role of dopamine D4 receptor ubiquitination and functional differences between the polymorphic receptor variants

The ubiquitination of the dopamine D4 receptor (DRD4), a G protein-coupled receptor (GPCR), is enhanced upon its interaction with a BTB-Kelch protein, KLHL12. We have shown that the KLHL12-induced DRD4 polyubiquitination does not play a key role in receptor degradation. In the current research we are investigating the role of ubiquitination in receptor signaling.