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Project

Nanobody-based Proximity Ligation Assay for Human Toxocariasis (FWOAL676)

In Human toxocariasis, severe disease may issue from infection with one single Toxocara larva. Diagnosis is difficult because the parasite does not replicate in the host and is located in tissues. Serological tests remain the least invasive and most sensitive approach to detect parasite antigens (Ags), but have thus far lacked sensitivity and specificity. Novel approaches are urgently needed to deliver tests of clinical and epidemological relevance. Our strategy exploits the advantages of two powerful techniques to address these needs: Nanobodies (Nbs) and the Proximity Ligation Assay (PLA).
Date:1 Jan 2013 →  31 Dec 2016
Keywords:Applied Biology
Disciplines:Clinical toxicology, Systems biology