< Back to previous page

Project

Translational research on chronic rejection after lung transplantation: Restrictive Allograft Syndrome after lung transplantation: exploring pathophysiological mechanisms and targeted therapy

Chronic lung allograft dysfunction (CLAD), the clinical correlate of chronic rejection, is the principal cause of late morbidity, mortality and excessive health-care costs following lung transplantation. The exact patho-physiological mechanisms in CLAD are incompletely understood. We will investigate risk factors for and mechanisms leading to CLAD, particulary for the phenotype called 'Restrictive Allograft Syndrome' (RAS), as well as novel preventive and treatment options. This will be performed by clinical intervention trials, epidemiologic studies, biobank analyses of human lung and blood samples; and possibly in vitro research using human airway cells and a murine model. The overall aim is to impro ve the long term outcome after lung transplantation.
Date:1 Oct 2015 →  30 Sep 2017
Keywords:chronic rejection, lung transplantation, pathophysiological mechanisms, targeted therapy, Restrictive Allograft Syndrome
Disciplines:Respiratory medicine