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Project

Protective effect of xenon on ischemia-reperfusion injury in renal transplantation.

Despite originally being described as chemically inert, the noble gas xenon has been repeatedly demonstrated to exhibit remarkable biological properties. Xenon is described as having many of the characteristics of an ideal inhalational anaesthetic agent. Xenon affects haemodynamic, myocardial performance and the neurohumoral system less than other anaesthetic agents. Furthermore, xenon was found to induce both early and late pharmacological preconditioning in experimental models of myocardial ischemia and has been demonstrated to offer neuroprotection in various animal models of neuronal injury. Xenon may also protect other organs from ischemia-reperfusion injury. In human tubular kidney cells and in rodents, xenon has been demonstrated to offer protection against renal ischemic injury. We hypothesize that administration of xenon by inhalation minimizes renal ischemia reperfusion injury in kidney transplantation. This hypothesis will be tested using current laboratory gold standard methodology, i.e., in a porcine model of kidney autotransplantation.
Date:1 Dec 2013 →  31 Dec 2015
Keywords:Xenon, Ischemia reperfusion injury, Kidney transplantation, Anesthesia, Pig.....
Disciplines:Laboratory medicine, Palliative care and end-of-life care, Regenerative medicine, Other basic sciences, Other health sciences, Nursing, Other paramedical sciences, Other translational sciences, Other medical and health sciences