Project
Characterization of Transient Receptor Potential (TRP) in human endometrium: in health and disease.
In the proposed research project we aim to provide insights into the functional role of mechanosensitive ion channels (focusing on Piezo 1, Piezo 2, TRPV4, TRPC1 and TRPC6) in the process of prostaglandin E2 (PGE2) release and production required for decidualization and embryo implantation. Interestingly, preliminary data obtained via quantitative RT-PCR on endometrium of fertile mothers showed increased expression levels of specific mechanosensitive ion channels during the implantation window. Using a murine artificial decidualization model and pharmacological inhibition of mechanosensitive ion channels, we aim to investigate the functional role of mechanosensitive ion channels in the process of decidualization in rodents. Furthermore, we aim to study the role of mechanosensitive ion channels in embryo implantation in humans We hereby propose a thorough investigation that is delineated by the following targets.