Researcher
Alexandre Denadai Souza
- Disciplines:Endocrinology and metabolic diseases, Gastro-enterology and hepatology, Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences
Affiliations
- Translational Research in GastroIntestinal Disorders (Division)
Member
From2 Oct 2017 → Today
Projects
1 - 6 of 6
- Unravelling aberrant host-microbiota interactions underlying intestinal epithelial barrier failure in cirrhosisFrom7 Feb 2024 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Harnessing Single-Cell and Spatial Transcriptomics to Uncover Novel Insights into Intestinal Barrier Breach in CirrhosisFrom1 Oct 2023 → TodayFunding: Fund Recuperation Fiscal Exemption, BOF - projects
- Characterizing Cellular Perturbations in the Intestinal Epithelial Barrier of Patients with CirrhosisFrom1 Oct 2022 → TodayFunding: BOF - projects
- Spectral flowcytometry (Cytek Aurora)From1 Jan 2021 → 31 Dec 2022Funding: BOF - scientific equipment program
- Transcriptional and Functional Characterization of Enterochromaffin cells in Irritable Bowel SyndromeFrom1 Jan 2020 → 31 Dec 2023Funding: FWO research project
- Proteases as novel target to treat visceral hypersensitivityFrom1 Sep 2017 → 31 Oct 2023Funding: FWO fellowships
Publications
1 - 8 of 8
- Colitis Linked to Endoplasmic Reticulum Stress Induces Trypsin Activity Affecting Epithelial Functions(2021)
Authors: Alexandre Denadai Souza
Pages: 1528 - 1541 - The Interplay Between Genetic Risk Factors and Proteolytic Dysregulation in the Pathophysiology of Inflammatory Bowel Disease(2020)
Authors: Alexandre Denadai Souza
Pages: 1149 - 1161 - Sexual dimorphism in PAR(2)-dependent regulation of primitive colonic cells(2019)
Authors: Julie Noguerol, Pierre-Jean Roustan, Mikael N'Taye, Leo Delcombel, Corinne Rolland, Laura Guiraud, David Sagnat, Anissa Edir, Chrystelle Bonnart, Alexandre Denadai Souza, et al.
- Active thrombin produced by the intestinal epithelium controls mucosal biofilms(2019)
Authors: Jean-Paul Motta, Alexandre Denadai Souza, David Sagnat, Laura Guiraud, Anissa Edir, Chrystelle Bonnart, Mireille Sebbag, Perrine Rousset, Ariane Lapeyre, Carine Seguy, et al.
- FAK alternative splice mRNA variants expression pattern in colorectal cancer(2019)
Authors: Christel Devaud, Anne-Francoise Tilkin-Mariame, Alix Vignolle-Vidoni, Philippine Souleres, Alexandre Denadai Souza, Corinne Rolland, Christine Duthoit, Catherine Blanpied, Sophie Chabot, Pascale Bouille, et al.
Pages: 494 - 502 - 5-oxoETE triggers nociception in constipation-predominant irritable bowel syndrome through MAS-related G protein-coupled receptor D(2018)
Authors: Alexandre Denadai Souza
- Thrombin modifies growth, proliferation and apoptosis of human colon organoids: a protease-activated receptor 1-and protease-activated receptor 4-dependent mechanism(2018)
Authors: Morgane Sebert, Alexandre Denadai Souza, Muriel Quaranta, Claire Racaud-Sultan, Sophie Chabot, Philippe Lluel, Nicolas Monjotin, Laurent Alric, Guillaume Portier, Sylvain Kirzin, et al.
Pages: 3656 - 3668 - Functional Proteomic Profiling of Secreted Serine Proteases in Health and Inflammatory Bowel Disease(2018)
Authors: Alexandre Denadai Souza, Chrystelle Bonnart, Nuria Sola Tapias, Marlene Marcellin, Brendan Gilmore, Laurent Alric, Delphine Bonnet, Odile Burlet-Schiltz, Morley D Hollenberg, Nathalie Vergnolle, et al.