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Project

Control theoretic characterization of advanced systems biology models

With increasing complexity of biotechnological processes, the associated process control needs to be based on more accurate computational models to maintain efficient operation. Systems biology research has led to new modeling techniques in the past decade, but the mathematical structure of these models is not amenable to current methods of control engineering. This project will provide methods for online monitoring and control of biosystems that are based on constraint based and cell population models. One challenge is that for these models, even basic systems properties like observability or controllability are not well characterized. Obtaining such a characterization will open the way to methods to monitor and control advanced bioprocesses more accurately and efficiently compared to the state of the art.
Date:1 Oct 2016 →  30 Sep 2018
Keywords:biology models
Disciplines:Biomaterials engineering, Biological system engineering, Biomechanical engineering, Other (bio)medical engineering, Environmental engineering and biotechnology, Industrial biotechnology, Other biotechnology, bio-engineering and biosystem engineering, Control systems, robotics and automation, Design theories and methods, Mechatronics and robotics, Computer theory