Impact of the bacterial colonic fermentation on future colorectal cancer risk after bariatric surgery.

Bariatric surgery is an effective way to treat obesity. Roux-en-Y gastric bypass (RYGB) reduces the gastric volume and bypasses parts of the small intestine so that malabsorption is induced whereas Sleeve Gastrectomy (SG) only reduces the volume of the stomach without inducing malabsorption. Although bariatric surgery reduces overall cancer risk, evidence indicates that the risk for colorectal cancer is increased and might depend on the type of surgery. We hypothesize that bariatric surgery modifies the bacterial colonic fermentation which contributes to the future CRC risk. A one-year follow-up study will be conducted in obese patients undergoing bariatric surgery. Blood and fecal samples will be collected prior to and at specific time points after surgery. We will characterize the colonic fermentation by analyzing metabolite profiles of the fecal samples and compare their capacity to induce toxicity in cultured colonic cells. Also the contribution of inflammation to toxicity will be taken into account.

Keywords:colorectal cancer

Disciplines:Morphological sciences, Oncology