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Project

Short circuits in the neuronal network. A role for B-type lamins?

Long-term adaptations of the brain, such as memory formation, rely on a delicate dialogue between neurons that is typified by intensive remodeling of both cellular and nuclear morphology. Recent observations suggest an important role for B-type lamins in neurodevelopment. We suspect that lamins interfere with neuronal plasticity via their architectural function in the nucleus. However, the exact mechanisms remain to be determined. Using a combined strategy of molecular profiling and deep imaging approaches, we aim at exposing a novel link between lamins and neuronal function. This way, we intend to further our understanding of a new phenotypical branch in the rapidly expanding tree of laminopathies and identify potential novel biomarkers or drug targets with relevance for the even larger spectrum of neurodevelopmental disorders.
Date:1 Oct 2017 →  30 Sep 2019
Keywords:NEURONAL PLASTICITY, NUCLEUS, LAMINOPATHIES, MICROSCOPY
Disciplines:Neurosciences, Animal cell and molecular biology, Cytoskeleton, Neurological and neuromuscular diseases, Neurosciences not elsewhere classified
Project type:Collaboration project