Sumitava Dastidar

My current research focuses on muscular dystrophy mainly Myotonic Dystrophy type1 (DM1) and Duchenne muscular dystrophy (DMD). The research revolves around understanding the disease mechanism and validating approaches to correct the disorder. My research involves development of a cellular disease model using patient derived iPSC cells and further understanding the underlying molecular mechanisms associated with aberrant alternative splicing in DM1. The study advanced with application of designer nuclease (CRISPR-Cas9) and transposon based molecular intervention to correct the disease phenotype.

My current research focuses on muscular dystrophy mainly Myotonic Dystrophy type1 (DM1) and Duchenne muscular dystrophy (DMD). The research revolves around understanding the disease mechanism and validating approaches to correct the disorder. My research involves development of a cellular disease model using patient derived iPSC cells and further understanding the underlying molecular mechanisms associated with aberrant alternative splicing in DM1. The study advanced with application of designer nuclease (CRISPR-Cas9) and transposon based molecular intervention to correct the disease phenotype.