Researcher
Dirk Tourwe
- Research Expertise:
- organische synthese peptide synthese massaspectrometrie HPLC analyse
- Keywords:Chemistry (incl. biochemistry), General and logistic services
- Users of research expertise:
- organische synthese peptide synthese massaspectrometrie HPLC analyse
Affiliations
- Organic Chemistry (Research group)
Member
From31 Dec 1999 → Today - Vriendenkring VUB (Office)
Member
From1 Oct 2012 → Today - Chemistry (Department)
Member
From1 Oct 2012 → 30 Sep 2022 - Chemistry (Department)
Member
From1 Jun 1996 → 30 Sep 2022 - Organic Chemistry (Research group)
Member
From1 Oct 1974 → 30 Sep 1991
Projects
1 - 3 of 3
- TheraVIP: Design of a VPAC1 neureceptor/neoligand couple for cellular therapy of dentritic cells against inflammatory diseasesFrom1 Jun 2008 → 31 May 2011Funding: Brussels Capital Region
- New heterocyclic scaffolds for conformationally constrained peptide- and peptide mimetic design.From1 Jan 2008 → 31 Dec 2011Funding: FWO research project (including WEAVE projects)
- Development of new peptide conjugates for radiolabeling.From1 Jan 2008 → 31 Dec 2008Funding: FWO research grant KAN
Publications
1 - 10 of 83
- Comprehensive overview of biased pharmacology at the opioid receptors: biased ligands and bias factors(2021)
Authors: Jolien De Neve, Thomas Barlow, Dirk Tourwé, Frederic Bihel, Frederic Simonin, Steven Ballet
Pages: 828-870 - Structure-Based Design of Melanocortin 4 Receptor Ligands Based on the SHU-9119-hMC4R Cocrystal Structure †(2020)
Authors: Charlotte Martin, Luis E. Gimenez, Savannah Y. Williams, Yu Jing, Yiran Wu, Charlie Hollanders, Olivier Van der Poorten, S Gonzalez, K Van Holsbeeck, Santo Previti, et al.
Pages: 357-369 - Optimized Opioid-Neurotensin Multitarget Peptides: From Design to Structure-Activity Relationship Studies(2020)
Authors: S Gonzalez, Maria Dumitrascuta, Emilie Eiselt, Stevany Louis, Linda Kunze, Annalisa Blasiol, Melanie Vivancos, Santo Previti, Elke Dewolf, Charlotte Martin, et al.
Pages: 12929-12941 - Neuromedin U and Structural Analogs. IF (2019) 3,946(2020)
Authors: An De Prins, Ann Van Eeckhaut, Ilse Smolders, Dirk Tourwé, Steven Ballet
Pages: 6744-6768 - Neurotensin Analogues Containing Cyclic Surrogates of Tyrosine at Position 11 Improve NTS2 Selectivity Leading to Analgesia without Hypotension and Hypothermia(2019)
Authors: Emilie Eiselt, S Gonzalez, Charlotte Martin, Magali Chartier, Cecilia Betti, Jean-Michel Longpre, Florine Cavelier, Dirk Tourwé, Louis Gendron, Steven Ballet, et al.
Pages: 4535-4544 - Synthesis and in Vitro Evaluation of Stabilized and Selective Neuromedin U-1 Receptor Agonists(2018)
Authors: An De Prins, Charlotte Martin, Yannick Van Wanseele, Csaba Tömböly, Dirk Tourwé, Vicky Caveliers, Birgitte Holst, Ann Van Eeckhaut, Mette Marie Rosenkilde, Ilse Smolders, et al.
Pages: 496–501 - Indoloazepinone-Constrained Oligomers as Cell-Penetrating and Blood-Brain-Barrier-Permeating Compounds. IF 2.593(2018)
Authors: Olivier Van der Poorten, Baptiste Legrand, Lubomir L. Vezenkov, Julia Garcia-Pindado, Nadir Bettache, Astrid Knuhtsen, Daniel Sejer Pedersen, Macarena Sanchez-Navarro, Jean Martinez, Meritxell Teixido, et al.
Pages: 696-705 - Development of potent and proteolytically stable human neuromedin U receptor agonists(2018)
Authors: An De Prins, Charlotte Martin, Yannick Van Wanseele, Louise Julie Skov, Csaba Tömböly, Dirk Tourwé, Vicky Caveliers, Ann Van Eeckhaut, Birgitte Holst, Mette Marie Rosenkilde, et al.
Pages: 887-897 - Rapid construction of substituted 3-amino-1,5-benzothiazepin-4(5H)-one dipeptide scaffolds through an Ugi-4CR - Ullmann cross-coupling sequence. IF 3.49(2018)
Authors: Olivier Van der Poorten, Robin Van Den Hauwe, Charlie Hollanders, Dirk Tourwé, Mouhamad Jida, Steven Ballet
Pages: 1242-1246 - Efficient One-Pot Access to Trisubstituted 2-Benzazepin-3-ones as Constrained Pseudopeptide Analogues and Privileged Scaffolds. IF 2.53(2018)
Authors: Olivier Van der Poorten, Mouhamad Jida, Dirk Tourwé, Steven Ballet
Pages: 400-408