Organisation
Liver Connexin and Pannexin Research Group
Research Group
The research topic of LCPR is the study of the use of connexins and pannexins as drug targets and biomarkers for the therapy and diagnosis of acute and chronic liver disease.
Projects
1 - 7 of 7
- H2020: Ontology-driven and artificial intelligence-based repeated dose toxicity testing of chemicals for next generation risk assessmentFrom1 May 2021 → TodayFunding: H2020-EU.3.1. - SOCIETAL CHALLENGES - Health, demographic change and wellbeing
- Cellular communication as target and biomarker in liver disease and toxicity: from basic research towards clinical applicationFrom1 Jan 2021 → TodayFunding: BOF - Methusalem
- Production of next generation modulators of pannexins and connexins as novel therapeutics in the treatment of inflammatory cardiovascular, hepatic and joint diseases.From1 Mar 2020 → TodayFunding: H2020-EU.1.2.- EXCELLENT SCIENCE - Future and Emerging Technologies (FET)
- GEAR: Brussels Liver Research to Valorisation Alliance (B-Liver): Valorisation of VUB’s liver cell biology and toxicology expertise via a consortium focused on liver therapeutics, patient and consumer safety.From1 Jan 2020 → TodayFunding: IOF - technology concept exploration, IOF - mandates
- CONNECT-2-CLINIC: Connexin and pannexin peptidomimetics and nanobodies for the clinical treatment of liver disease.From1 Jan 2020 → 31 Dec 2021Funding: H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)
- Connexin hemichannels and pannexin channels as mediators and in vitro indicators of drug-induced cholestatic liver injury.From1 Nov 2019 → 31 Oct 2023Funding: FWO fellowships
- Are connexins, pannexins and their (hemi)channels novel biomarkers and pharmacological targets in the prognosis and therapy of liver cancer? (Toekenning in het kader van bilaterale onderzoekssamenwerking met Brazilië)From1 Jan 2019 → 31 Dec 2021Funding: FWO research project (including WEAVE projects)
Publications
1 - 10 of 98
- Liver adverse outcome pathways: what's in for the hepatologist?(2020)
Authors: Mathieu Vinken
Pages: 659-664 - Key performance indicators of the contemporary European academic toxicologist(2019)
Authors: Mathieu Vinken, Heather Wallace
Pages: 1775-1776 - Establishment and Characterization of an In Vitro Model of Fas-Mediated Hepatocyte Cell Death(2015)Series: Methods in Molecular BiologyVolume: 1250
Authors: Mathieu Vinken, Michael Maes, Sara Crespo Yanguas, Joost Willebrords, Tamara Vanhaecke, Vera Rogiers
Pages: 95-103Number of pages: 8 - Rodent models of cholestatic liver disease: a practical guide for translational research(2021)
Authors: Eva Gijbels, Alanah Pieters, Kevin De Muynck, Mathieu Vinken, Lindsey Devisscher
Pages: 656-682 - Hepatotoxicity induced by nanomaterials: mechanisms and in vitro models(2021)
Authors: Vânia Vilas-Boas, Mathieu Vinken
Pages: 27-52 - "Watching the Detectives" report of the general assembly of the EU project DETECTIVE Brussels, 24-25 November 2015(2016)
Authors: Ruani Fernando, Umesh Chaudhari, Sylvia Escher, Jan Hengstler, Jurgen Hescheler, Paul Jennings, Hector Keun, Jos Kleinjans, Kolde Raivo, Kollipara Laxmikanth, et al.
Pages: 1529-1539 - Connexin32 deficiency is associated with liver injury, inflammation and oxidative stress in experimental non-alcoholic steatohepatitis(2017)
Authors: Taynã Tiburcio, Joost Willebrords, Isabel Veloso Alves Pereira, Michael Maes, Cintia Maria Monteiro de Araújo, Sara Crespo Yanguas, Tereza Cristina da Silva, Maria Lucia Zaidan Dagli, Mathieu Vinken, Bruno Cogliati
Pages: 197-206 - Burdock (Arctium lappa L.) root attenuates preneoplastic lesion development in a diet and thioacetamide-induced model of steatohepatitis-associated hepatocarcinogenesis(2020)
Authors: Guilherme R. Romualdo, Elizangela Dos Anjos Silva, Tereza Cristina da Silva, Thiago P.A. Aloia, Marina S. Nogueira, Inar A. de Castro, Mathieu Vinken, Luís F Barbisan, Bruno Cogliati
Pages: 518-527 - Models and methods for in vitro testing of hepatic gap junctional communication(2015)
Authors: Michael Maes, Sara Crespo Yanguas, Joost Willebrords, Mathieu Vinken
Pages: 569-577 - Experimental models of liver fibrosis(2016)
Authors: Sara Crespo Yanguas, Bruno Cogliati, Joost Willebrords, Michael Maes, Isabelle Colle, Bert Van den Bossche, Claudia Pinto Marques Souza de Oliveira, Wellington Andraus, Venâncio Avancini Ferreira Alves, Isabelle Leclercq, et al.
Pages: 1025-1048