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High-risk human papillomavirus types in HIV-infected and HIV-uninfected young women in KwaZulu-Natal, South Africa

Journal Contribution - Journal Article

Subtitle:implications for vaccination
Background: High-risk human papillomavirus (hr-HPV) infections and low-grade squamous intraepithelial lesions occur frequently in young women. The available vaccines cover up to seven hr-HPV genotypes (HPV16, HPV18, HPV31, HPV33, HPV45, HPV52 and HPV58) and two low-risk HPV types (HPV6 and HPV11). The objective of this study was to describe the hr-HPV genotypes present among HIV-uninfected and HIV-infected young women in rural high schools. Methods: Cervicovaginal lavages were obtained from sexually active young women recruited from high schools in KwaZulu-Natal (n=1223). HPV testing was done by the polymerase chain reaction using GP5+/GP6+primers and enzyme immunoassay. HIV testing was done using rapid test kits. Results: Of the 1223 cervicovaginal lavages, 301 (25%) were positive for hr-HPV. The HPV prevalence was higher in HIV infected (32.20%, 95% CI: 0.27-0.38) than in HIV-uninfected women (22.50%, 95% CI: 0.21-0.26), (p=.001). Similarly, multiple infections were slightly more common in HIV infected (59.32%) than in HIV-uninfected women (53.51%), (p=.37). The nine predominant genotypes in descending order were HPV types 16 (n=99, 22.10%), 51 (n=58, 12.91%), 18 (n=56, 12.50%), 35 (n=50, 11.10%), 33 (n=47, 10.82%), 56 (n=42, 9.31%), 45 (n=34, 7.60%), 52 (n=32, 7.14%) and 59 (n=31, 6.91%). HPV 35, 51, 56 and 59 (40.62%), which are not covered by any vaccine, were among the most prevalent in the schools of KwaZulu-Natal. Conclusion: Four of the most predominant high-risk HPV types in this region are not covered by the new nine-valent HPV vaccine.
Journal: Infectious Diseases
ISSN: 2374-4243
Volume: 49
Pages: 601 - 608
Keywords:A1 Journal article
BOF-keylabel:yes
BOF-publication weight:1
CSS-citation score:1
Authors:International
Authors from:Higher Education
Accessibility:Closed