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Publication

HIV Nef: Role in pathogenesis and viral fitness

Journal Contribution - Review Article

Conserved in all primate lentivirus genomes, Nef promotes viral replication and infectivity, influences the trafficking of a large number of surface receptors and interferes with TCR signalling, consequently modulating T-cell activation. In vivo observations with Long Term Non-Progressors harbouring a Nef-defective HIV and vaccination studies with Nef-deleted SIV in Rhesus macaques have shown a prominent role for Nef in lentiviral pathogenesis. Here we review the functions of Nef involved in viral replication and infectivity and speculate on a possible role for Nef in HIV fitness.
Journal: CURRENT HIV RESEARCH
ISSN: 1570-162X
Issue: 3
Volume: 6
Pages: 200 - 208
Publication year:2008