< Back to previous page

Project

Investigation and quantification of the osteogenic potential of high frequency loading in implant osseointegration.

Bone metabolism around biomaterials is a dynamic process that is characterized by continuous bone formation and resorption. Hormonal and mechanical factors influence bone formation and -homeostasis around implants. Considering the evidence of the anabolic effect of controlled mechanical stimulation on the initial phase of implant osseointegration and of high-frequency (10-100 Hz) mechanical stimulation on bone regeneration and adaptation, in particular in case of hormonal deficiency, this loading parameter will be our target variable for investigation of an accelerated and enhanced regeneration of the bone tissue in general and around an implant. The impact of the load frequency, in relation to the load amplitude and mode of application, on the dynamics of the tissue response at the bone-implant interface in optimal and osteopenic bone conditions will be investigated by animal experiments. Numerical and biomechanical analyses will examine the load transfer and propagation of anabolic high frequency mechanical stimuli throughout the bone tissue and in the implant surroundings.
Date:1 Jan 2009 →  31 Dec 2012
Keywords:loading, high frequency, vibration, remodeling, bone, Implants
Disciplines:Biomechanics, Applied mathematics in specific fields, Computer architecture and networks, Distributed computing, Information sciences, Information systems, Programming languages, Scientific computing, Theoretical computer science, Visual computing, Other information and computing sciences, Morphological sciences