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Project

The development and validation of myocardial compartment models for the assessment and follow-up of regional functional and perfusion magnetic resonance data in acute myocardial infarction.

To develop analysis tools to evaluate regional function, perfusion and viability in physiologically and clinically relevant compartments of the left ventricular wall (i.e. infarct core, peri-infarct zone and remote myocardium) in the acute myocardial infarct setting using merging of late-gadolinium enhancement, cine and perfusion magnetic resonance imaging (MRI) data. Late gadolinium enhancement (LGE) MRI provides highly accurate in-vivo data on the location and extent of irreversible myocardial damage and is nowadays considered as the reference for infarct sizing in both the acute and the chronic setting. Rather than using a fixed approach using the ventricular anatomy, the presence and extent of LGE can be used to precisely define the infarct core among the LV myocardium, the surrounding (peri-infarct) region, and the remainder (i.e. remote) myocardium. The compartments defined as such, have the advantage to reflect myocardial tissue with similar characteristics, which might be a better approach to evaluate regional parameters such as myocardial function, and the effects of the novel therapeutic strategies.
Date:1 Jan 2009 →  31 Dec 2012
Keywords:Cardial magnetic resonance
Disciplines:Diagnostics, Laboratory medicine, Medicinal products, Cardiac and vascular medicine, Medical imaging and therapy, Other paramedical sciences