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Project

Natural history and predictive value of left ventricular structure and function in a general population.

Approximately 1000 randomly selected subjects, who underwent high-fidelity echocardiography over the past 4 years (2005-2008) will be re-invited for a follow-up echocardiographic examination. They will also be followed up for the incidence of mortality and morbidity to address 4 research questions: 1.To trace the natural history of LV function in subjects with and without LV dysfunction at baseline; 2.To explore dysregulation of arterio-ventricular coupling as a potential pathophysiological mechanism in subclinical systolic and diastolic LV dysfunction; 3.To identify markers predictive of the natural history of LV function, over and beyond those already known; 4.To predict the incidence of fatal and non-fatal outcomes from high-tech innovative echocardiographic indices , such as, myocardial velocities, LV strain and strain rate, and LV torsion, as measured by TDI and tissue tracking, respectively.
Date:1 Jan 2009 →  31 Dec 2012
Keywords:Epidemiology
Disciplines:Public health care, Public health sciences, Public health services, Cardiac and vascular medicine