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Project

Nucleotides, nucleic acids and their analogues as tools or targets for inhibitor design.

With the exception of modifications of the pyrophosphate group itself, modifications of the leaving groups of nucleoside triphosphate for the enzymatic polymerization of nucleic acids got little attention. We will investigate synthesis, biochemistry, structural and analytical aspects of this new chemistry with potential application in biotechnology, drug design and synthetic biology. A second part of the project involves the study of secondary RNA structure and their potential use for inhibitor design. NMR spectroscopy will be used to determine the three dimensional structure of an RNA sequence that contains a cis-acting element crucial for regulation of the Hepatitis E virus replication. This will allow us to use this sequence as a new target for inhibitor design.
Date:1 Oct 2009 →  30 Sep 2014
Keywords:Nucleic acids, Hepatitis E virus, NMR, Leaving groups, Nucleotides, Organic chemistry
Disciplines:Laboratory medicine, Medical systems biology, Medicinal chemistry