The impact of reperfusion therapy on the perfusion-function-load relationship in the different substrates of chronic ischemic haert disease.

Restoration of perfusion to the chronic ischemic myocardium can reverse the unfavorable process of remodeling and leads to a better pump function. Both preprocedural and therapeutic interventions are costly and risky. This is why, in clinical practice, possible remodeling and functional improvement are evaluated using non invasive imaging. Despite appropriate imaging still a significant part of interventions remain without effect. This is due on one side to methodological problems (which modality/parameter is optimal) and on the other side to the physio-pathologic problem (the response of the ischemic ventricle to therapy is poorly understood). To answer the methodological question we will study a large number of patients in the Doppler-CIP trial. For the path-physiologic problem we will us an established model of choric ischemia developed in our department; this model has been validated and quantified extensively using MR imaging and echo for perfusion, deformation, shape and cellular characterization. We will reopen the stent used in this model to study the effects of acute reperfusion on local and regional function and the cellular changes involved in this acute process.

Keywords:Chronic ischemia, Pig modelµMagnetic resonance imaging, Hibernation, Reperfusion

Disciplines:Medical imaging and therapy, Other paramedical sciences, Cardiac and vascular medicine