< Back to previous page
Project
Matricellular proteins: crucial regulators of cardiac remodeling
Heart Failure (HF) affects over 15 million Europeans and results in increased hospitalization and mortality. </>The major causes of heartfailure are ischemic heart disease, hypertension and viral infection ofthe heart. </>
With the increasing mean age of the global population, the incidence of HF is increasing and the number of patients at risk of developing this condition is expected to grow. </>Despite clinical standards, improved medical technologies, better understanding of thepathogenesis of heart failure is essential to improve diagnosis and treatment strategies. </>This project describes the role of a subset of matricellular proteins (MCPs) and their clinical implications in heart disease. </>Generally, this project adds new insights regarding cardiac remodeling during physiological aging, viral myocarditis or after myocardial infarction directing to improve treatment of heart disease and emphasizes the potential of matricellular proteins to influence intracellular signaling cascades and provides novel insights to develop diagnostic tools for clinical implications in cardiovascular disease.</>
With the increasing mean age of the global population, the incidence of HF is increasing and the number of patients at risk of developing this condition is expected to grow. </>Despite clinical standards, improved medical technologies, better understanding of thepathogenesis of heart failure is essential to improve diagnosis and treatment strategies. </>This project describes the role of a subset of matricellular proteins (MCPs) and their clinical implications in heart disease. </>Generally, this project adds new insights regarding cardiac remodeling during physiological aging, viral myocarditis or after myocardial infarction directing to improve treatment of heart disease and emphasizes the potential of matricellular proteins to influence intracellular signaling cascades and provides novel insights to develop diagnostic tools for clinical implications in cardiovascular disease.</>
Date:1 Oct 2009 → 31 Mar 2010
Keywords:Matricellular proteins, Heart failure, Cardiomyopathy
Disciplines:Cardiac and vascular medicine, Laboratory medicine, Palliative care and end-of-life care, Regenerative medicine, Other basic sciences, Other health sciences, Nursing, Other paramedical sciences, Other translational sciences, Other medical and health sciences
Project type:PhD project