Researcher
Séan Mc Cafferty
- Disciplines:Food sciences and (bio)technology, Other chemical sciences, Other agricultural, veterinary and food sciences, Molecular and cell biology, Systems biology, Nutrition and dietetics, Animal biology, Veterinary medicine, Other veterinary sciences, Agricultural animal production, Genetics
Affiliations
- Department of Veterinary and Biosciences (Department)
Member
From9 Jan 2015 → 24 Sep 2023
Projects
1 - 2 of 2
- An mRNA replicon based immunotherapeutic combinational treatment for triple negative breast cancerFrom1 Jan 2016 → 31 Dec 2019Funding: FWO Strategic Basic Research Grant
- OVDS Sean Mc Cafferty: Drug-controllable protein expression forOVOS Sean Mc Cafferty: Drug-controllable protein expression form IL-12 encoding modified mRNA.From1 Jan 2016 → 31 Dec 2016Funding: FWO Humanitarian research project Stand up against Cancer
Publications
1 - 10 of 14
- A dual-antigen self-amplifying RNA SARS-CoV-2 vaccine induces potent humoral and cellular immune responses and protects against SARS-CoV-2 variants through T cell-mediated immunity(2022)
Authors: Séan Mc Cafferty, A. K. M. Ashiqul Haque, Aster Vandierendonck, Brian Weidensee, Magalie Plovyt, Magdalena Stuchlikova, Nathalie François, Sophie Valembois, Leo Heyndrickx, Johan Michiels, et al.
Pages: 2968 - 2983 - Corticosteroids and cellulose purification improve, respectively, the in vivo translation and vaccination efficacy of sa-mRNAs(2021)
Authors: Séan Mc Cafferty, Lisa Opsomer, Haixiu Wang, Hanne Huysmans, Joyca De Temmerman, Stefan Lienenklaus, Francis Combes, Niek Sanders
Pages: 1370 - 1381 - In Vivo Validation of a Reversible Small Molecule-Based Switch for Synthetic Self-Amplifying mRNA Regulation(2021)
Authors: Séan Mc Cafferty, Joyca De Temmerman, Tasuku Kitada, Jacob R. Becraft, Ron Weiss, Darrell J. Irvine, Mathias Devreese, Francis Combes, Niek Sanders
Pages: 1164 - 1173 - Expression kinetics and innate immune response after electroporation and LNP-mediated delivery of a self-amplifying mRNA in the skin(2019)
Authors: Hanne Huysmans, Joyca De Temmerman, Barbara L Mui, Ying K Tam, Séan Mc Cafferty, Arlieke Gitsels, Niek Sanders
Pages: 867 - 878 - Bovine embryo-secreted microRNA-30c is a potential non-invasive biomarker for hampered preimplantation developmental competence(2019)
Authors: Xiaoyuan Lin, Evy Beckers, Séan Mc Cafferty, Yannick Gansemans, Katarzyna Joanna Szymańska-Vandendriessche, Krishna Pavani, João Portela Catani, Filip Van Nieuwerburgh, Dieter Deforce, Petra De Sutter, et al.
- Improving the repeatability and efficacy of intradermal electroporated self-replicating mRNA(2019)
Authors: Hanne Huysmans, Joyca De Temmerman, Séan Mc Cafferty, Francis Combes, Niek Sanders
Pages: 388 - 395 - Immunogenicity and protection efficacy of a naked self-replicating mRNA-based Zika virus vaccine(2019)
Authors: Zifu Zhong, João Paulo Portela Catani, Séan Mc Cafferty, Liesbeth Couck, Wim Van Den Broeck, Nina Gorlé, Roosmarijn Vandenbroucke, Bert Devriendt, Sebastian Ulbert, Lieselotte Cnops, et al.
- Mononuclear but not polymorphonuclear phagocyte depletion increases circulation times and improves mammary tumor-homing efficiency of donor bone marrow-derived monocytes(2019)
Authors: Francis Combes, Alexandros Marios Sofias, Séan Mc Cafferty, Hanne Huysmans, Joyca De Temmerman, Sjoerd Hak, Evelyne Meyer, Niek Sanders
- mRNA therapeutics deliver a hopeful message(2018)
Authors: Séan Mc Cafferty, Francis Combes, Hanne Huysmans, Joyca De Temmerman, Arlieke Gitsels, Niek Sanders
Pages: 16 - 39 - Off-target and tumor-specific accumulation of monocytes, macrophages and myeloid-derived suppressor cells after systemic injection(2018)
Authors: Francis Combes, Séan Mc Cafferty, Niek Sanders
Pages: 848 - 856