Researcher
Sigrid Verhasselt
- Disciplines:Transport phenomena, Other chemical sciences, Separation and membrane technologies, Process engineering, General chemical and biochemical engineering, Chemical product design and formulation, Catalysis and reacting systems engineering, Other (bio)chemical engineering, Agricultural plant production
Affiliations
- Department of Green Chemistry and Technology (Department)
Member
From1 Jan 2018 → 23 Sep 2018 - Department of Sustainable Organic Chemistry and Technology (Department)
Member
From4 Sep 2013 → 31 Dec 2017
Projects
1 - 1 of 1
- Development of small-molecule inhibitors of nonmuscle myosin II as chemical tools and antimetastatic therapeutics (CONFIDENTIAL)From1 Oct 2013 → 30 Sep 2017Funding: BOF - Doctoral projects
Publications
1 - 10 of 12
- Discovery of (S)-3U+2032-hydroxyblebbistatin and (S)-3U+2032-aminoblebbistatin : polar myosin II inhibitors with superior research tool properties(2017)
Authors: Sigrid Verhasselt, Kristof Van Hecke, Rik Van Deun, Marc Bracke, Christian Stevens
Pages: 2104 - 2118 - Development of novel blebbistatin derivatives in the quest for improved non-muscle myosin II inhibitors(2017)
Authors: Sigrid Verhasselt
- Further studies on anti-invasive chemotypes: an excursion from chalcones to curcuminoids(2015)
Authors: Tine De Ryck, Sigrid Verhasselt, Marc Bracke, Christian Stevens
Pages: 1021 - 1025 - On the quest for new anti-invasive agents: from the discovery of 4-fluoro-3',4','5'-trimethoxychalcone to its initial validation in an in vivo metastasis model(2014)
Authors: Tine De Ryck, Sigrid Verhasselt, Alan Katritzky, Marc Bracke, Christian Stevens
Number of pages: 1 - Feruloyl benzotriazole and Weinreb amide as bioinspired building blocks: a reactivity study
Authors: Jean-Christophe Monbaliu, Laurens De Coen, Sigrid Verhasselt, Christian Stevens
Number of pages: 1 - Insights into the myosin II inhibitory potency of A-ring-modified (S)-blebbistatin analogs
Authors: Sigrid Verhasselt, Christian Stevens, Tom Van den broecke, Marc Bracke
Pages: 2986 - 2989 - Discovery of anti-invasive tools and leads for the study and treatment of metastatic cancer : two case studies
Authors: Sigrid Verhasselt, Marc Bracke, Christian Stevens
Number of pages: 1 - Medicinal chemistry and use of myosin II inhibitor (S)-blebbistatin and its derivatives
Authors: Bart Roman, Sigrid Verhasselt, Christian Stevens
Pages: 9410 - 9428 - Synthesis of C-ring-modified blebbistatin derivatives and evaluation of their myosin II ATPase inhibitory potency
Authors: Sigrid Verhasselt, Christophe Mangodt, Olivier De Wever, Christian Stevens
Pages: 2261 - 2264 - Feruloylbenzotriazole and Weinreb amide as bioinspired building blocks: a reactivity study towards O-, N-, S-, and C- nucleophiles
Authors: Jean-Christophe Monbaliu, Laurens De Coen, Sigrid Verhasselt, Bart Schuddinck, Evelien Van Hoeylandt, Christian Stevens
Pages: 2594 - 2611